Sean Wattegedera

sean.wattegedera@moredun.ac.uk

Moredun Research Institute
Pentlands Science Park
Bush Loan
Penicuik
Midlothian EH26 0PZ

Biography

Sean Wattegedera joined Moredun in 1999 following his undergraduate degree in Biological Sciences (Hons) at Lancaster University. In 2004 Sean became a Research Scientist. Sean has an interest in cytokine biology and host immunity to Chlamydia spp.. Sean is primarily involved in the development, characterisation and application of immunological reagents to investigate disease pathogenesis in both sheep and cattle.

Current Research

Currently working on RERAD Workpackage 2.2 Host Immunity to Chlamydia spp.
Within the Immunology Theme on the development, characterisation and application of immunological reagents to investigate cytokine biology in sheep and cattle.
Commercialisation of immunological reagents for use as research tools.

Selected Key Publications

Wattegedera, S.R., Watson, D.M., Hope, J.C., Kaiser, P., Sales, J., McInnes, C.J., Entrican, G. 2010. Relative quantitative kinetics of interferon-gamma and interleukin-10 mRNA and protein production by activated ovine peripheral blood mononuclear cells Veterinary Immunology and Immunopathology 136(1-2):34-42.
Wheelhouse, N., Wattegedera, S.R., Stanton, J., Maley, S.W., Watson, D., Jepson, C., Deane, D., Buxton, D., Longbottom, D., Baszler, T. 2009. Ovine trophoblast is a primary source of TNFα during Chlamydophila abortus infection Journal of Reproductive Immunology 80(1-2):49 - 56.
Wheelhouse, N.M., Wattegedera, S.R., Fleming, D., Fitch, P., Kelly, R., Entrican, G. 2008. Chlamydia trachomatis and Chlamydophila abortus induce the expression of secretory leukocyte protease inhibitor in cells of the human female reproductive tract Microbiology and Immunology 52(9):465 - 468.
Rocchi, M., Wattegedera, S.R., Meridiani, I., Entrican, G. 2009. Protective adaptive immunity to Chlamydophila abortus infection and control of ovine enzootic abortion (OEA) Veterinary Microbiology 135(1-2):112 - 121.
Entrican, G., Wattegedera, S.R., Rocchi, M., Wheelhouse, N. 2009. Pregnancy, indoleamine 2,3-dioxygenase (IDO) and chlamydial abortion: An unresolved paradox Veterinary Microbiology 135(1-2):98 - 102.
Wattegedera, S.R., Rocchi, M., Sales, J., Howard, C., Hope, J., Entrican, G. 2008. Antigen-specific peripheral immune responses are unaltered during normal pregnancy in sheep Journal of Reproductive Immunology 77(2):171 - 178.
French, A., Bethune, J., Knight, P., McNeilly, T.N., Wattegedera, S.R., Rhind, S., Miller, H., Pemberton, A. 2007. The expression of intelectin in sheep goblet cells and upregulation by interleukin-4☆ Veterinary Immunology and Immunopathology 120(1-2):41 - 46.
Hope, J., Kwong, L., Thom, M., Sopp, P., Mwangi, W., Brown, W., Palmer, G., Wattegedera, S.R., Entrican, G., Howard, C. 2005. Development of detection methods for ruminant interleukin (IL)-4 Journal of Immunological Methods 301(1-2):114 - 123.
Wattegedera, S.R., Sills, K., Howard, C., Hope, J., McInnes, C., Entrican, G. 2004. Variability in cytokine production and cell proliferation by mitogen-activated ovine peripheral blood mononuclear cells: modulation by interleukin (IL)-10 and IL-12 Veterinary Immunology and Immunopathology 102(1-2):67 - 76.
Entrican, G., Wattegedera, S.R., Chui, M., Oemar, L., Rocchi, M., McInnes, C. 2002. Gamma interferon fails to induce expression of Indoleamine 2,3-Dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells Infection and Immunity 70(5):2690 - 2693.

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Sean Wattegedera

Biography

Current Research

Selected Key Publications

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