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Dr David Longbottom

Dr David Longbottom

Moredun Research Institute
Pentlands Science Park
Bush Loan
Penicuik
Midlothian EH26 0PZ

Biography

David graduated from Manchester University in 1985 with a BSc Honours in Biochemistry and from Edinburgh University in 1989 with a PhD in biochemistry on the effects of cholera toxin on intracellular signalling in enterocytes. His first post-doctoral position was a 4-year project at the MRC Human Genetics Unit in Edinburgh on the tissue localisation of the product of the Cystic Fibrosis gene, the Cystic Fibrosis Transmembrane Conductance Regulator.

He moved to Moredun in 1993, taking a post within Moredun Animal Health (now Moredun Scientific) on a commercially-funded project developing vaccines for controlling nematode infections. In 1994 he was appointed as a postdoctoral scientist on an EU-funded Third Framework project developing better detection systems for chlamydial infections of farm livestock and zoonotic infections of man. In August 1997 he was appointed Head of the Molecular Chlamydiology group at Moredun, and as Molecular Biology Theme Leader for the Institute in 2003. He is currently a Senior Principal Research Scientist, leading a group investigating the pathogenesis and control of chlamydial infections in ruminants and also Head of Diagnostics. Since 2002 he has been responsible for the OIE (World Organisation for Animal Health) chapter on Enzootic Abortion of Ewes (Ovine Chlamydiosis) and since 2008 he has been scientific editor for Research in Veterinary Science

Current Research

  • Understanding the mechanisms by which chlamydial pathogens cause disease and the interaction between host and pathogen (SG Programme Research 2016-21).
  • Identifying and characterizing the components that can be used in the control of chlamydial infections through genomic, bioinformatic, molecular and proteomic approaches (SG Programme Research 2016-21).
  • Development of improved control strategies for Ovine Chlamydiosis, including improved vaccines, vaccine delivery systems and diagnostic tools (SG Programme Research 2016-21).
  • Chlamydia abortus genome sequencing project to investigate strain variation and diversity in collaboration with Nick Thomson and Helena Seth-Smith (Wellcome Trust Sanger Institute), as well as colleagues in Europe, US and N. Africa.
  • Development of computational and analytical metagenomic pipelines for analysing microbial populationsand host response associated with disease syndromes or vectors, and changes in populations resulting from different external factors (SG Programme Research 2016-21).

Selected Key Publications