Dr David Griffiths

david.griffiths@moredun.ac.uk

Moredun Research Institute
Pentlands Science Park
Bush Loan
Penicuik
Midlothian EH26 0PZ

Biography

David Griffiths graduated from the University of Manchester in 1992 with a BSc in Biochemistry. He gained a PhD in Virology from the University of London in 1996 for his studies on the potential role of retroviruses in human rheumatic disease. Following a short postdoctoral position at the Chester Beatty Laboratories London, in 1998 he was awarded an Arthritis Research Council Postdoctoral Fellowship at University College London. In 2003, he moved to the Moredun Research Institute as a Principal Scientist. Dr Griffiths has a longstanding interest in retroviral pathogenesis and his current research focusses on understanding the pathogenesis of ovine pulmonary adenocarcinoma and the development of diagnostic tests for controlling this disease. He is a member of the BBSRC Pool of Experts and a former Scientific Editor of Research in Veterinary Science.

David's ResearchGate profile

Current Research

Development of control strategies for ovine pulmonary adenocarcinoma
Virus-host interactions in ovine pulmonary adenocarcinoma
Ex vivo lung tissue models of respiratory viruses
Ovine pulmonary adenocarcinoma as a model for human lung cancer
Development of lentiviral vectors for vaccine delivery in ruminants.

Selected Key Publications

Youssef, G., Wallace, W.A.H., Dagleish, M.P., Cousens, C., Griffiths, D.J. 2015. Ovine pulmonary adenocarcinoma: a large animal model for human lung cancer ILAR Journal 56(1):99-115.
Cousens, C., Alleaume, C., Bijsmans, E., Martineau, H.M., Finlayson, J., Dagleish, M.P., Griffiths, D.J. 2015. Jaagsiekte sheep retrovirus infection of lung slice cultures Retrovirology 12():31.
Entrican, G., Wattegedera, S.R., Griffiths, D.J. 2015. Exploiting ovine immunology to improve the relevance of biomedical models Molecular Immunology 66(1):68-77.
Caporale, M., Martineau, H., De las Heras, M., Murgia, C., Huang, R., Centorame, P., Di Francesco, G., Di Gialleonardo, L., Spencer, T.E., Griffiths, D.J., Palmarini, M. 2013. Host species barriers to Jaagsiekte sheep retrovirus replication and carcinogenesis Journal of Virology 87(19):10752-10762.
Martineau, H.M., Dagleish, M.P., Cousens, C., Underwood, C., Forbes, V., Palmarini, M., Griffiths, D.J. 2013. Cellular differentiation and proliferation in the ovine lung during gestation and early postnatal development Journal of Comparative Pathology 149(2-3):255-267.
Martineau, H.M., Cousens, C., Imlach, S., Dagleish, M.P., Griffiths, D.J. 2011. Jaagsiekte Sheep Retrovirus infects multiple cell types in the ovine lung Journal of Virology 85(7):3341-3355.
Hopwood, P., Wallace, W.A.H., Cousens, C., Dewar, P., Muldoon, M., Norval, M., Griffiths, D.J. 2010. Absence of markers of betaretrovirus infection in human pulmonary adenocarcinoma Human Pathology 41(11):1631-1340.
Griffiths, D.J., Martineau, H.M., Cousens, C. 2010. Pathology and pathogenesis of ovine pulmonary adenocarcinoma Journal of Comparative Pathology 142(4):260-283.
Voisset, C., Weiss, R.A., Griffiths, D.J. 2008. Human RNA "Rumor" viruses: the search for novel human retroviruses in chronic disease Microbiology and Molecular Biology Reviews 72(1):157-196.
Karagianni, A.Eleonora, Vasoya, D., Finlayson, J., Martineau, H.M., Wood, A.R., Cousens, C., Dagleish, M.P., Watson, M., Griffiths, D.J. 2019. Transcriptional response of ovine lung to infection with jaagsiekte sheep retrovirus Journal of Virology 93(21):e00876-19.
Gray, M.E., Sullivan, P., Marland, J.R.K., Greenhalgh, S.N., Meehan, J., Gregson, R., Clutton, E., Cousens, C., Griffiths, D.J., Murray, A., Argyle, D. 2019. A novel translational ovine pulmonary adenocarcinoma model for human lung cancer Frontiers in Oncology 9():534.
Gray, M.E., Meehan, J., Sullivan, P., Marland, J.R.K., Greenhalgh, S.N., Gregson, R., Clutton, R.Eddie, Ward, C., Cousens, C., Griffiths, D.J., Murray, A., Argyle, D. 2019. Ovine pulmonary adenocarcinoma: a unique model to improve lung cancer research Frontiers in Oncology 9():335.

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Dr David Griffiths

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