Dr Dave Bartley

dave.bartley@moredun.ac.uk

Moredun Research Institute
Pentlands Science Park
Bush Loan
Penicuik
Midlothian EH26 0PZ

Biography

I graduated from East London University in 1995 with a BSc (Hons) Infectious Diseases and began work at Moredun in 1995. In 2008 I was awarded my PhD from Edinburgh University for work on ‘Prevalence, characterisation and management of anthelmintic resistance in gastro-intestinal nematodes of Scottish sheep’.

My current interests are improving diagnostics and control strategies for nematode infections of ruminants. Currently having projects looking at a) the development and dissemination of anthelmintic resistance in Nematodirus battus. b) the development and generation of genomic resources for sequencing, applying markers of anthelmintic resistance in the field to assess the effectiveness and impact of different control strategies on worm populations and the translation of results to relevant stakeholders. c) the factors that influence farmer’s attitudes and behaviours with respect to nematode control and d) identifying and characterisation monepantel resistance.

I actively participate in the promotion of best practice roundworm control in ruminants and my work has been used to inform and update government and levy board publications on the best practice advice for producers (e.g. Sustainable Control of Parasites of Sheep; SCOPS and Control of Worms sustainably; COWS).

Current Research

Scottish Government Higher Education Institute link with Glasgow University, Monepantel: anthelmintic resistance and the development of tools for sustainable use. Moredun Lead investigator
BBSRC Strategic LoLa (BB/M003949/1). The BUG consortium Building Upon the Genome: using H. contortus genomic resources to develop novel interventions to control endemic GI parasites. 2015-2020, Co-investigator
AHDB. Development of molecular tools for the rapid assessment of benzimidazole resistance and investigation of possible factors in resistance development in Nematodirus battus populations. 2014-2017, PhD Scholarship, Lead Investigator
INRA, Toulouse. Ability of ABC transporter inhibitor to reverse macrocyclic lactone resistance in in vivo efficacy trial in sheep. 2014, Collaborator
DEFRA/Veterinary Medicines Directorate. A study to consider prescribing groups and distribution channels to ensure appropriate use of anthelmintics in the UK. 2013-2015. Co-applicant

Selected Key Publications

Bartley, D.J., Mesle, M., Donegan, H., Devin, L., Morrison, A.A. 2016. Phenotypic assessment of the ovicidal activity of monepantel and monepantel sulfone on gastro-intestinal nematode eggs Veterinary Parasitology 220():87-92.
Bartley, D.J., Skuce, P.J., Zadoks, R.N., MacLeod, M. 2016. Endemic sheep and cattle diseases and greenhouse gas emissions Advances in Animal Biosciences 7(03):253 - 255.
Easton, S., Pinchbeck, G.L., Bartley, D.J., Hotchkiss, E., Hodgkinson, J.E., Matthews, J.B. 2016. A survey of UK prescribers’ experience of, and opinions on, anthelmintic prescribing practices for livestock and equines Preventive Veterinary Medicine 134():69 - 81.
Easton, S., Bartley, D.J., Hotchkiss, E., Hodgkinson, J.E., Pinchbeck, G.L., Matthews, J.B. 2016. Use of a multiple choice questionnaire to assess UK prescribing channels’ knowledge of helminthology and best practice surrounding anthelmintic use in livestock and horses Preventive Veterinary Medicine 128():70 - 77.
Easton, S., Pinchbeck, G.L., Tzelos, T., Bartley, D.J., Hotchkiss, E., Hodgkinson, J.E., Matthews, J.B. 2016. Investigating interactions between UK horse owners and prescribers of anthelmintics Preventive Veterinary Medicine 135():17 - 27.
Özkan, Ş., Vitali, A., Lacetera, N., Amon, B., Bannink, A., Bartley, D.J., Blanco-Penedo, I., Haas, Y., Dufrasne, I., Elliott, J., Eory, V., Fox, N.J., Garnsworthy, P.C., Gengler, N., Hammami, H., Kyriazakis, I., Leclère, D., Lessire, F., Macleod, M., Robinson, T.P., Ruete, A., Sandars, D.L., Shrestha, S., Stott, A.W., Twardy, S., Vanrobays, M.L., Ahmadi, B.V., Weindl, I., Wheelhouse, N., Williams, A.G., Williams, H.W., Wilson, A.J., Østergaard, S., Kipling, R.P. 2016. Challenges and priorities for modelling livestock health and pathogens in the context of climate change Environmental Research 151():130 - 144.
Rose Vineer, H., Steiner, J., Knapp-Lawitzke, F., Bull, K., Son-de Fernex, E., Bosco, A., Hertzberg, H., Demeler, J., Rinaldi, L., Morrison, A.A., Skuce, P., Bartley, D.J., Morgan, E.R. 2016. Implications of between-isolate variation for climate change impact modelling of Haemonchus contortus populations Veterinary Parasitology 229():144 - 149.
McBean, D., Nath, M., Kenyon, F., Zile, K., Bartley, D.J., Jackson, F. 2016. Faecal egg counts and immune markers in a line of Scottish Cashmere goats selected for resistance to gastrointestinal nematode parasite infection Veterinary Parasitology 229():1 - 8.
Bartley, D.J., Devin, L., Nath, M., Morrison, A.A. 2015. Selection and characterisation of monepantel resistance in Teladorsagia circumcincta isolates International Journal for Parasitology: Drugs and Drug Resistance 5(2):69 - 76.
Laing, R., Kikuchi, T., Martinelli, A., Tsai, I.J., Beech, R.N., Redman, E., Holroyd, N., Bartley, D.J., Beasley, H., Britton, C., Curran, D., Devaney, E., Gilabert, A., Hunt, M., Jackson, F., Johnston, S.L., Kryukov, I., Li, K., Morrison, A.A., Reid, A.J., Sargison, N., Saunders, G.I., Wasmuth, J.D., Wolstenholme, A., Berriman, M., Gilleard, J.S., Cotton, J.A. 2013. The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery Genome Biology 14(8):R88.

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Dr Dave Bartley

Biography

Current Research

Selected Key Publications

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