Dr Dave Bartley

Moredun Research Institute
Pentlands Science Park
Bush Loan
Penicuik
Midlothian EH26 0PZ

Biography

I graduated from the University of East London in 1995 with a BSc (Hons) Infectious Diseases and began work at Moredun later that year. In 2008 I was awarded my PhD from Edinburgh University for work on the ‘Prevalence, characterisation and management of anthelmintic resistance in gastro-intestinal nematodes of Scottish sheep’.

I continue to have a keen interest in anthelmintic resistance research, particularly in areas around improving diagnostics and control strategies for nematode infections of ruminants. Currently I have projects looking at a) Transmission risks of animal movement and wildlife in the dissemination of nematodes species; b) the development and generation of genomic resources for sequencing, applying markers of anthelmintic resistance in the field to assess the effectiveness and impact of different control strategies on worm populations; c) identifying and characterisation monepantel resistance and d) the factors that influence farmer’s attitudes and behaviours with respect to nematode control.

I actively participate in the promotion of best practice roundworm control in ruminants and my work has been used to inform and update government, levy board and industry led initiative (e.g. Sustainable Control of Parasites of Sheep; SCOPS and Control of Worms sustainably; COWS) publications on the best practice advice for stakeholders.

Current Research

Parasitic nematodes an evolving problem: Understanding drug resistance progression and transmission and developing tools to improve mitigation strategies Veterinary Medicines Directorate and DEFRA, Principal Investigator 2019-2022
Worms, sheep and environment: integrating ecological perspectives into resistance management NERC case studentship 2018-2022
COMBatting Anthelmintic Resistance in ruminants (COMBAR;), EU COST action CA16230 – Working group leader 2018-2021
Scottish Government Higher Education Institute link with Glasgow University, Monepantel: anthelmintic resistance and the development of tools for sustainable use. Moredun Lead investigator
The BUG consortium Building Upon the Genome: using H. contortus genomic resources to develop novel interventions to control endemic GI parasites. BBSRC Strategic LoLa (BB/M003949/1). 2015-2020, Co-investigator

Selected Key Publications

Turnbull, F., Devaney, E., Morrison, A.A., Laing, R., Bartley, D.J. 2019. Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta International Journal for Parasitology: Drugs and Drug Resistance 11():59-69.
Redman, E., Queiroz, C., Bartley, D.J., Levy, M., Avramenko, R.W., Gilleard, J.S. 2019. Validation of ITS-2 rDNA nemabiome sequencing for ovine gastrointestinal nematodes and its application to a large scale survey of UK sheep farms Veterinary Parasitology 275():108933.
Kipling, R.P., Topp, C.F.E., Bannink, A., Bartley, D.J., Blanco-Penedo, I., Cortignani, R., del Prado, A., Dono, G., Faverdin, P., Graux, A.I., Hutchings, N.J., Lauwers, L., Gülzari, Ö., Reidsma, P., Rolinski, S., Ruiz-Ramos, M., Sandars, D.L., Sándor, R., Schönhart, M., Seddaiu, G., van Middelkoop, J., Shrestha, S., Weindl, I., Eory, V. 2019. To what extent is climate change adaptation a novel challenge for agricultural modellers? Environmental Modelling & Software 120():104492.
Sargison, N.D., MacLeay, M., Morrison, A.A., Bartley, D.J., Evans, M., Chaudhry, U. 2019. Development of amplicon sequencing for the analysis of benzimidazole resistance allele frequencies in field populations of gastrointestinal nematodes International Journal for Parasitology: Drugs and Drug Resistance 10():92-100.
Hogan, G., Walker, S., Turnbull, F., Curiao, T., Morrison, A.A., Flores, Y., Andrews, L., Claesson, M.J., Tangney, M., Bartley, D.J. 2019. Microbiome analysis as a platform R&D tool for parasitic nematode disease management The ISME Journal 13():2664-2680.
Macrelli, M., Williamson, S., Mitchell, S., Pearson, R., Andrews, L., Morrison, A.A., Nevel, M., Smith, R., Bartley, D.J. 2019. First detection of ivermectin resistance in oesophagostomum dentatum in pigs Veterinary Parasitology 270():1 - 6.
Morgan, E.R., Aziz, N.A.A., Blanchard, A., Charlier, J., Charvet, C., Claerebout, E., Geldhof, P., Greer, A.W., Hertzberg, H., Hodgkinson, J., Höglund, J., Hoste, H., Kaplan, R.M., Valladares, M.Martínez, Mitchell, S., Ploeger, H.W., Rinaldi, L., Samson-Himmelstjerna, G., Sotiraki, S., Schnyder, M., Skuce, P., Bartley, D., Kenyon, F., Thamsborg, S.M., Vineer, H.Rose, Waal, T., Williams, A.R., van Wyk, J.A., Vercruysse, J. 2019. 100 questions in livestock helminthology research Trends in Parasitology 35(1):52-71.
Doyle, S.R., Illingworth, C.J.R., Laing, R., Bartley, D.J., Redman, E., Martinelli, A., Holroyd, N., Morrison, A.A., Rezansoff, A., Tracey, A., Devaney, E., Berriman, M., Sargison, N., Cotton, J.A., Gilleard, J.S. 2019. Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus BMC Genomics 20():218.
Bartley, D.J., Hamer, K., Andrews, L., Sargison, N.D., Morrison, A.A. 2019. Multigeneric resistance to monepantel on a UK sheep farm Veterinary Parasitology: X 1():100003.
Avramenko, R.W., Redman, E.M., Melville, L., Bartley, Y., Wit, J., Queiroz, C., Bartley, D.J., Gilleard, J.S. 2018. Deep amplicon sequencing as a powerful new tool to screen for sequence polymorphisms associated with anthelmintic resistance in parasitic nematode populations International Journal for Parasitology 49(1):13-26.
Bartley, D.J., Mesle, M., Donegan, H., Devin, L., Morrison, A.A. 2016. Phenotypic assessment of the ovicidal activity of monepantel and monepantel sulfone on gastro-intestinal nematode eggs Veterinary Parasitology 220():87-92.
Bartley, D.J., Skuce, P.J., Zadoks, R.N., MacLeod, M. 2016. Endemic sheep and cattle diseases and greenhouse gas emissions Advances in Animal Biosciences 7(3):253-255.
Easton, S., Pinchbeck, G.L., Bartley, D.J., Hotchkiss, E., Hodgkinson, J.E., Matthews, J.B. 2016. A survey of UK prescribers’ experience of, and opinions on, anthelmintic prescribing practices for livestock and equines Preventive Veterinary Medicine 134():69-81.
Easton, S., Bartley, D.J., Hotchkiss, E., Hodgkinson, J.E., Pinchbeck, G.L., Matthews, J.B. 2016. Use of a multiple choice questionnaire to assess UK prescribing channels’ knowledge of helminthology and best practice surrounding anthelmintic use in livestock and horses Preventive Veterinary Medicine 128():70-77.
Easton, S., Pinchbeck, G.L., Tzelos, T., Bartley, D.J., Hotchkiss, E., Hodgkinson, J.E., Matthews, J.B. 2016. Investigating interactions between UK horse owners and prescribers of anthelmintics Preventive Veterinary Medicine 135():17-27.
Özkan, Ş., Vitali, A., Lacetera, N., Amon, B., Bannink, A., Bartley, D.J., Blanco-Penedo, I., Haas, Y., Dufrasne, I., Elliott, J., Eory, V., Fox, N.J., Garnsworthy, P.C., Gengler, N., Hammami, H., Kyriazakis, I., Leclère, D., Lessire, F., Macleod, M., Robinson, T.P., Ruete, A., Sandars, D.L., Shrestha, S., Stott, A.W., Twardy, S., Vanrobays, M.L., Ahmadi, B.V., Weindl, I., Wheelhouse, N., Williams, A.G., Williams, H.W., Wilson, A.J., Østergaard, S., Kipling, R.P. 2016. Challenges and priorities for modelling livestock health and pathogens in the context of climate change Environmental Research 151():130-144.
Rose Vineer, H., Steiner, J., Knapp-Lawitzke, F., Bull, K., Son-de Fernex, E., Bosco, A., Hertzberg, H., Demeler, J., Rinaldi, L., Morrison, A.A., Skuce, P., Bartley, D.J., Morgan, E.R. 2016. Implications of between-isolate variation for climate change impact modelling of Haemonchus contortus populations Veterinary Parasitology 229():144-149.
McBean, D., Nath, M., Kenyon, F., Zile, K., Bartley, D.J., Jackson, F. 2016. Faecal egg counts and immune markers in a line of Scottish Cashmere goats selected for resistance to gastrointestinal nematode parasite infection Veterinary Parasitology 229():1-8.
Bartley, D.J., Devin, L., Nath, M., Morrison, A.A. 2015. Selection and characterisation of monepantel resistance in Teladorsagia circumcincta isolates International Journal for Parasitology: Drugs and Drug Resistance 5(2):69-76.
Laing, R., Kikuchi, T., Martinelli, A., Tsai, I.J., Beech, R.N., Redman, E., Holroyd, N., Bartley, D.J., Beasley, H., Britton, C., Curran, D., Devaney, E., Gilabert, A., Hunt, M., Jackson, F., Johnston, S.L., Kryukov, I., Li, K., Morrison, A.A., Reid, A.J., Sargison, N., Saunders, G.I., Wasmuth, J.D., Wolstenholme, A., Berriman, M., Gilleard, J.S., Cotton, J.A. 2013. The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery Genome Biology 14():R88.

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Dr Dave Bartley

Biography

Current Research

Selected Key Publications

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