Bill is an infectious disease immunologist having completed a PhD in Immunology at the University of Colorado Medical Center and postdoctroral work in human T cell leukemia virus at University of Colorado at Boulder. He then worked on tick borne diseases at the Center for Disease Control and Stony Brook University before joining the Exotic diseases group at Plum Island Animal Disease Center. Bill’s lab at Plum Island studied the immune response of cattle and swine to infection with foot-and-mouth disease virus and vaccine performance in those species. In 2016, Bill moved to Scotland to join the Moredun Research Institute.
The Golde lab’s current focus is development of vaccines for viral infections of livestock that induce a strong cellular immune response to compliment the anti-virus antibody response induced using present vaccine formulations. We use vaccine vectors derived from various viruses including adenovirus and vaccinia virus to redesign the vaccine payload to be delivered in a manner that induces the critical cytotoxic T lymphocyte (CTL) response. This response kills virus infected cells and arrests the spread of virus within the body and between animals.