Professor Willie Donachie
Address:
Moredun Research Institute
Pentlands Science Park
Bush Loan
Penicuik
Midlothian EH26 0PZ
Scotland
Telephone Number:
+44 (0)131 445 5111
Email address:
Willie Donachie graduated from the University of Glasgow in 1978 with a BSc in Microbiology and immediately joined the staff at the Moredun Research Institute in Edinburgh, where he gained his PhD in 1984 for studies on experimental vaccines for Mannheimia haemolytica infections in ruminants. He is Deputy Director at Moredun and Head of Diagnostics and has specific research interests in bacterial diseases of livestock. In January 2011, Willie also became Managing Director of Moredun Scientific.
Vaccine development has been a major component of his research and has involved close links with commercial companies. The identification and patenting of bacterial iron-regulated outer membrane proteins as important immunogens for Pasteurella vaccines led to the development of commercially successful vaccines against pneumonia in sheep and cattle.
Willie is a visiting Professor at the University of Glasgow and an Honorary Fellow, Department of Veterinary Pathology, University of Edinburgh. He is the Chair of the Veterinary Advisory Committee of the Horserace Betting Levy Board and an International Member of the Molecular and Developmental Genetics Grant Selection Committee of the Natural Sciences and Engineering Research Council of Canada (NSERC).
Current Research:
Selected Key Publications:
Selected Key Publications
- Walker, C. A., Donachie W., Smith D. G. E., & Fontaine M. C. 2011. Targeted allele-replacement mutagenesis of Corynebacterium pseudotuberculosis.. Applied and Environmental Microbiology. (In press):.
- Forbes, A. B., Ramage C., Sales J., Baggott D., & Donachie W. 2011. Determination of the duration of antibacterial efficacy following administration of Gamithromycin using a bovine Mannheimia haemolytica challenge model. Antimicrobial Agents and Chemotherapy. 55(2):831 - 835.
- Murcia, P., Donachie W., & Palmarini M. 2009. Viral pathogens of domestic animals and their impact on biology, medicine and agriculture. Encyclopedia of Microbiology. ():805 - 819.
- Connor, K. M., Fontaine M. C., Rudge K., Baird G. J., & Donachie W. 2007. Molecular genotyping of multinational ovine and caprine Corynebacterium pseudotuberculosis isolates using pulsed-field gel electrophoresis. Veterinary Research. 38(4):613 - 623.
- Godinho, K., Benchaoui H. A., Tilt N., Ramage C., Quirie M., Donachie W., et al. 2007. Efficacy of danofloxacin in the treatment of pneumonic pasteurellosis in specific pathogen-free lambs. Veterinary Record. 160(22):770 - 771.
- Eckersall, P. D., Lawson F. P., Bence L., Waterston M. M., Lang T. L., Donachie W., et al. 2007. Acute phase protein response in an experimental model of ovine caseous lymphadenitis. BMC Veterinary Research. 3(1):35.
- Fontaine, M., Baird G., Connor K., Rudge K., Sales J., & Donachie W. 2006. Vaccination confers significant protection of sheep against infection with a virulent United Kingdom strain of Corynebacterium pseudotuberculosis. Vaccine. 24(33-34):5986 - 5996.
- Hariharan, H., Donachie W., Macaldowie C., & Keefe G. 2004. Bacteriology and somatic cell counts in milk samples from ewes on a Scottish farm. Canadian Journal of Veterinary Research. 68():188-192.
- Lainson, F. A., Aitchison K. D., Donachie W., & Thomson J. R. 2002. Typing of Pasteurella multocida isolated from pigs with and without porcine dermatitis and nephropathy syndrome. Journal of Clinical Microbiology. 40(2):588 - 593.
- Sarasola, P., Lees P., AliAbadi F. S., McKellar Q. A., Donachie W., Marr K. A., et al. 2002. Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolytica. Antimicrobial Agents and Chemotherapy. 46(9):3013 - 3019.