Professor Jacqui Matthews
Moredun Research Institute
Pentlands Science Park
Midlothian EH26 0PZ
After qualifying in veterinary medicine at the University of Glasgow, Jacqui’s career has been in parasitology research. Her research spans nematode vaccine development and diagnostic design and optimisation for sustainable worm control in ruminants and horses. She has had obtained over £13m in competitive grant funding to support her research and has published >110 associated peer-reviewed research papers. In addition to support from Scottish Government, her research has been/is funded by the BBSRC, Wellcome Trust, DEFRA-VMD, Horserace Betting Levy Board, Horse Trust, Pilkington Trust, Donkey Sanctuary , Perry Foundation, animal health companies and EU H2020. Currently, Jacqui is the Coordinator a 9m euro EU Horizon 2020 project, PARAGONE, which brings together 17 scientific and industrial partners from across the globe to develop novel vaccines for multicellular parasites. She is also Coordinator of the Scottish Government funded Strategic Partnership in Animal Science Excellence (SPASE; http://spasepartnership.org/).
Jacqui holds a ministerial appointment on the UK Veterinary Products Committee, with membership of committees on parasite control guidelines, animal welfare trustee boards and journal editorial boards. She lectures/examines regularly at several of the UK veterinary schools and often provides seminars on worms and their control to farmers, horse owners, SQPs and veterinarians. She has a strong commitment to post-graduate teaching and is Chair of Moredun’s Post-graduate Committee. Jacqui holds an Honorary Professorship at the Royal (Dick) School of Veterinary Studies, University of Edinburgh, and is Translational Facilitator of Edinburgh’s Centre of Immunity, Infection and Evolution (http://ciie.bio.ed.ac.uk/).
Jacqui’s vaccine research has focused on worm excreted/secreted (ES) molecules, thought to affect parasite development and survival in the host. The approach has proven successful with the discovery of a recombinant protein vaccine, based on Teladorsagia circumcincta (brown stomach worm) ES proteins, that induces significant immunity against challenge in sheep. This work defines the best levels of protection induced by any roundworm sub-unit vaccine in a ruminant host. Her group also studies anthelmintic resistance in horses and cattle; the main objectives here being to improve tools to detect resistance and to design support systems that facilitate evidence-based control. This research has been instrumental in developing tools to differentiate worm species, defining mechanisms of resistance and in optimizing diagnostic tests for animals managed under different conditions.
A selection of Jacqui's publications can be seen below or for a fuller list please click here.
2015-19: EU (Horizon 2020). PARAGONE: vaccines for animal parasites. JM PI & Coordinator, 17 partners. €8,998,500 .
2015-18: BBSRC: Animal Health Research Club. Dissecting variation in host responsiveness to a recombinant vaccine designed to control teladorsagiosis in sheep. JM PI, with AJ Nisbet, TN McNeilly, S Burgess (Moredun) & S Babyan (Glasgow). £612,089.
2015-18: Horse Trust. Taking evidence-based parasite control into the field: tools and training initiatives aimed at mitigating helminth-associated disease in horses. JM PI with JE Hodgkinson (Liverpool), ER Morgan (Bristol), S Burgess (MRI), T Mair (Bell Equine Clinic). £198,196.
2014-16: BBSRC Super Follow-on Fund. Technical development of a novel vaccine vehicle for cattle pathogens. With KR Matthews (PI, Edinburgh). £301,483.
2013-15: DEFRA/VMD. A study to consider prescribing groups and distribution channels to ensure appropriate use of anthelmintics in the UK. JM PI with JE Hodgkinson & G Pinchbeck (Liverpool), DJ Bartley & E Hotchkiss (Moredun). £266,364.
2013-17: NERC (PhD Scholarship. Underpinning knowledge on how resistance is spread amongst cattle helminth populations using NGS technology. With S Paterson (PI, Liverpool).
2013-16: Horserace Betting Levy Board. Development of tools to promote best practice parasite control on UK Thoroughbred studs. With JE Hodgkinson (PI, Liverpool). £122,465.
012-15: Donkey Sanctuary. Development and quantitative validation of improved sustainable parasite control programmes: creation and validation of a general monitoring and control system for endoparasites. With S Love & M Denwood (PIs, Glasgow). £88,472.
SG RESAS: Host/parasite interactions in teladorsagiosis. With A Nisbet and T McNeilly (Moredun).
Selected Key Publications
- Matthews, J. B. 2014. Anthelmintic resistance in equine nematodes. International Journal for Parasitology: Drugs and Drug Resistance.
- Ellis, S., Matthews J. B., Shaw D. J., Paterson S., McWilliam H. E. G., Inglis N. F., et al. 2014. Ovine IgA-reactive proteins from Teladorsagia circumcincta infective larvae. International Journal for Parasitology. 44(10):743-750.
- Hayward, A. D., Garnier R., Watt K. A., Pilkington J. G., Grenfell B. T., Matthews J. B., et al. 2014. Heritable, heterogeneous, and costly resistance of sheep against nematodes and potential feedbacks to epidemiological dynamics*. The American Naturalist. 184(S1):S58 - S76.
- Relf, V. E., Lester H. E., Morgan E. R., Hodgkinson J. E., & Matthews J. B. 2014. Anthelmintic efficacy on UK thoroughbred stud farms. International Journal for Parasitology. 44(8):507 - 514.
- Lester, H. E., & Matthews J. B. 2013. Faecal worm egg count analysis for targeting anthelmintic treatment in horses: Points to consider. Equine Veterinary Journal. 46(2):139-145.
- Nisbet, A. J., McNeilly T. N., Wildblood L. A., Morrison A. A., Bartley D. J., Bartley Y., et al. 2013. Successful immunization against a parasitic nematode by vaccination with recombinant proteins. Vaccine. 31(37):4017-4023.
Not a Member?
Moredun membership allows you to keep up to date with the latest advances in livestock health. You can join or renew your Moredun membership online.