Dr Tom McNeilly
Moredun Research Institute
Pentlands Science Park
Midlothian EH26 0PZ
Tom McNeilly joined Moredun in 2006 following the completion of his PhD at R(D)SVS, University of Edinburgh. He is a qualified veterinary surgeon, and prior to starting his PhD spent 4 years in mixed practice. His major interests are in mucosal immunology, specifically host-pathogen interactions at mucosal surfaces, and how these may inform future disease control strategies. In addition to exploring basic immunological questions in ruminant species, his work is also involved in the development of vaccines to control veterinary pathogens residing at mucosal surfaces, such as Escherichia coli O157:H7 in cattle and Teladorsagia circumcincta in sheep. He also has an interest in the immune basis of disease resistance and susceptibility in ruminant species.
- Development of vaccines against E. Coli O157:H7 and Teladorsagia circumcincta
- Investigation of immune-regulation in ruminants in relation to parasitic and bacterial diseases
- Identification of blood immune markers relating to disease susceptibility or resistance in ruminant populations
Selected Key Publications
- McNeilly, T. N., McIntyre J., Frew D., Griffiths D. J., Wattegedera S. R., van den Broek A., et al. 2009. Infestation of sheep with Psoroptes ovis, the sheep scab mite, results in recruitment of Foxp3 + T cells into the dermis. Parasite Immunology. 32(5):369.
- McNeilly, T. N., Mitchell M. C., Rosser T., McAteer S., Low C. J., Smith D. G. E., et al. 2010. Immunization of cattle with a combination of purified intimin-531, EspA and Tir significantly reduces shedding of Escherichia coli O157:H7 following oral challenge. Vaccine. 28(5):1422 - 1428.
- McNeilly, T. N., Mitchell M. C., Nisbet A. J., McAteer S., Erridge C., Inglis N. F., et al. 2010. IgA and IgG antibody responses following systemic immunization of cattle with native H7 flagellin differ in epitope recognition and capacity to neutralise TLR5 signalling. Vaccine. 28(5):1412 - 1421.
- McNeilly, T. N., Devaney E., & Matthews J. B. 2009. Teladorsagia circumcincta in the sheep abomasum: defining the role of dendritic cells in T cell regulation and protective immunity. Parasite Immunology. 31(7):347 - 356.
- McNeilly, T., McClure S., & Huntley J. 2008. Mucosal immunity in sheep and implications for mucosal vaccine development☆. Small Ruminant Research. 76(1-2):83 - 91.
- McNeilly, T. N., Naylor S. W., Mahajan A., Mitchell M. C., McAteer S., Deane D., et al. 2008. Escherichia coli O157:H7 colonization in cattle following systemic and mucosal immunization with purified H7 flagellin. Infection and Immunity. 76(6):2594 - 2602.
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