Dr Alasdair Nisbet
Moredun Research Institute
Pentlands Science Park
Midlothian EH26 0PZ
Alasdair Nisbet is Head of the Vaccines Pillar at Moredun. He graduated from Glasgow University with a BSc in Agricultural Zoology, followed by a PhD in Biochemistry. After postdoctoral periods at Aberdeen University and the University of Melbourne, he joined Moredun in 2004. Throughout his scientific career his research focus has been on novel methods of controlling invertebrate pests and parasites with an emphasis on understanding and exploiting the unique physiology of parasites of veterinary significance, in particular by understanding their interactions with the host.
He has worked in, and with, some of the most forward-thinking and effective academic research groups in the field and has national and international collaborations with, and funding from, RCUK and industry partners. He has fruitful collaborations with public sector and stakeholder groups nationally and internationally and has been highly successful in gaining research funding, holding ~£10M of external research funding (individually and collaboratively) currently.
Recent Research Highlights:
· The development and testing of a vaccine to control Teladorsagiosis, which provides the highest levels of protection observed in any system using a nematode recombinant sub-unit vaccine in the definitive host.
· The successful co-expression of multiple T. circumcincta vaccine candidates in a eukaryotic system
· The development and testing (in collaboration with Dr. Stewart Burgess) of a vaccine to control sheep scab, which reduced lesion size by >50% in vaccinated animals after challenge.
· The development and testing (in collaboration with Dr. John Huntley) of an autogenous vaccine to control poultry red mite, which reduced mite numbers by ca. 75% in vaccinated hens after challenge.
· The development (in collaboration with Drs. John Huntley and Stewart Burgess) of a lab-based serological test for sheep scab which has >98% sensitivity and 96.5% specificity.
Selected Key Publications
- Burgess, S. T. G., Nunn F., Nath M., Frew D., Wells B., Marr E. J., et al. 2016. A recombinant subunit vaccine for the control of ovine psoroptic mange (sheep scab). Veterinary Research. 47(1):26.
- Marr, E. J., Sargison N. D., Nisbet A. J., & Burgess S. T. G. 2015. Gene silencing by RNA interference in the house dust mite, Dermatophagoides pteronyssinus. Molecular and Cellular Probes. 29(6):522-526.
- Bartley, K., Wright H. W., Huntley J. F., Manson E. D. T., Inglis N. F., Mclean K., et al. 2015. Identification and evaluation of vaccine candidate antigens from the poultry red mite (Dermanyssus gallinae). International Journal for Parasitology .
- Nisbet, A. J., McNeilly T. N., Wildblood L. A., Morrison A. A., Bartley D. J., Bartley Y., et al. 2013. Successful immunization against a parasitic nematode by vaccination with recombinant proteins. Vaccine. 31(37):4017-4023.
- McNeilly, T. N., Rocchi M., Brown J. K., Frew D., Nisbet A. J., Wattegedera S., et al. 2013. Suppression of ovine lymphocyte activation by Teladorsagia circumcincta larval excretory-secretory products. Veterinary Research. 44():.
- Baker, R. H., Britton C., Roberts B., Loer C. M., Matthews J. B., & Nisbet A. J. 2012. Melanisation of Teladorsagia circumcincta larvae exposed to sunlight: A role for GTP-cyclohydrolase in nematode survival. International Journal for Parasitology. 42(10):887-891.
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