Moredun's MHC defined flock comprises animals homozygous for one of four common MHC haplotypes along with a large number of matched MHC heterozygous animals. Each of the MHC haplotypes has been extensively characterised at the genetic level with the important MHC class I and class II genes cloned, sequenced and expressed.
These sequences have provided the reference sequences for populating the sheep section of the immunopolymorphism database . This public database provides a source of information on MHC genetic diversity in domestic sheep. Its purpose is to collate data on allelic diversity and provide a forum for the analysis, verification and nomenclature of diversity in the genes and proteins of the ovine MHC.